Shkreli seems to have borderline personality disorder, among other things.
As for his profiteering on drugs, yes there should be controls on that sort of thing, which are matters of life and death. It seems to me that if antitrust laws don't cover it, it would only require a small modification to prevent gouging by a firm that has a monopoly on a drug.
I think coincidences can have an effect on some people's thinking if they internalize those coincidences, but do I think there is some external numerological web that causes coincidences to happen, in order to make a point? No.
For example, Halley's comet is said to have been in the sky during the battle of Hastings, which changed the course of Western history, but what happened in 1910, when that comet made a very bright appearance, causing widespread unease? If it was "meant" to be a portent of WW1, it was four years too early. Maybe the stars thought humankind needed a lot of notice in that case.