Well for me, I might have said it's when you discover that your own beloved USA is NOT about "freedom and justice for all," nor is it about "life, liberty and the pursuit of happiness;" rather the USA is more and more about the profit margin...
However, I am feeling a bit mystical today so I found this quote from the 13th century poet Rumi; "What is agony of the spirit? To advance toward death without seizing hold of the Water of Life."
So what do y'all think?